Cardiogen — Khavinson Peptide Research Archive

Heart-derived peptide; cardiovascular keyword matches in the DB include general cardiovascular pharmacology — read titles before citing.

Extract counterpart: None established — this compound exists only as a defined synthetic fragment.

Extract vs synthetic gap: the human outcome data (including the 266-patient mortality cohort) was collected on extracts; vendors sell synthetic fragments. No head-to-head trial exists — evidence does not transfer between them. Details →

Khavinson studies (12 matched, 1991–2023)

Keyword-filtered from the 472-publication database (khavinson.info). EXTRACT/SYNTHETIC tags are title-text heuristics — verification is on the reader. Full tag legend: evidence-tiers.html

[1] [Khavinson V., Linkova N., Dyatlova A., Kantemirova R., Kozlov K. Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation. // Cells. – 2023. – Vol. 12, Iss. 1, 106. – 22 p.](https://khavinson.info/assets/files/skan/2023-khavinson_linkova_dyatlova.pdf) DOI: 10.3390/cells12010106 (2023)syn DOI:10.3390/cells12010106 [PDF]

[15] Khavinson V., Linkova N., Ivko O. AEDG Peptide Regulates the Expression of Circadian Genes Clock, Cry2, Csnk1e in Human Immune Cells. // World Heart Journal. – 2021. – Vol. 13, Iss. 1. – P. 189-191. (2021)untag [PDF]

[33] [Boldueva S.A., Petrova V.B., Khavinson V.Kh., Samohvalova M.V., Petrova A.I. Problems in the Diagnostics and Treatment of Transtiretinum Amyloidosis with Heart Disease in the Elderly: Clinical Experience. // Advances in Gerontology. – 2019. – Vol. 9, N 4. – P. 466-471.](https://khavinson.info/assets/files/skan/2019-boldueva.pdf) DOI: 10.1134/S2079057019040039 (2019)untag DOI:10.1134/S2079057019040039 [PDF]

[137] Anisimov S.V., Khavinson V.Kh., Anisimov V.N. Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray. // Neuroendocrinology Letters. - 2004. - Vol. 25. N 1/2. - P. 87-93. (2004)untag [PDF]

[160] Anisimov S.V., Bokheler K.R., Khavinson V.Kh., Anisimov V.N. Studies of the Effects of Vilon and Epithalon on Gene Expression in Mouse Heart using DNA-Microarray Technology. // Bulletin of Experimental Biology and Medicine. - 2002. - Vol. 133, N 3. - P. 293-299. (2002)ext [PDF]

[208] Baranovskaya S., Kudinov S., Fomicheva E., Vasina V., Solovieva D, Khavinson V., Schwartz E. Age as a risk factor for myocardial infarction in Leiden mutation carriers. // Molecular genetics and metabolism. - 1998. - Vol. 63. - P. 155-157. (1998)ext [PDF]

[186] Khavinson V.Kh., Solovyova D.V. Genetic predisposition to the ischemic heart disease in the elderly. // The Gerontologist. Special issue 1. -1999. - V. 39. - P. 150. (1999)untag

[191] Solovyova D., Khavinson V., Schwarts E. Genetic predisposition to fibrinolytic abnormality as an important risk factor for ischemic heart disease in the elderly. // Mechanisms of ageing and longevity: Abstr. of the Symposium. - England. - 1999. - P. 12. (1999)untag

[213] Solovyova D.V., Khavinson V.Kh., Schwarts E.I. Molecular-genetic investigation and prevention of cardiovascular pathology development. // Abstr. of the International Conference on Biomedical Aspects of Aging Research. - Venice, Italy. - 1997. - C-7: P-58. (1997)untag

[225] Pavlenko V.S., Rosenshtein Yu.B., Andreeva L.I., Merkurjeva G.A., Khavinson V.Kh. Heart peptides in treatment of ischemic heart disease (IHD) and reperfusion damage. // Vth World Conference on Clinical Pharmacology and Therapeutics. - Yokohama, Japan. - Abstr. - 1992. - P. 95. (1992)untag

[229] Yakovlev G.M., Khavinson V.Kh., Andreeva L.I., Ershov V.I. The peptide correction of ischmic myocardial damages. // Abstr. of the Constituent Congress of International Society for Pathophysiology. - 1991. - P. 93. (1991)untag

[230] Yakovlev G.M., Khavinson V.Kh., Pavlenko V.S., Andreeva L.I., Ershov V.I., Merkurjeva G.A. Heart peptides - a new antiischemic preparation. // 4th International Symposium on Cardiovascular Pharmacotherapy “Cardiovascular drugs and therapy”. - Abstr.: Cardiovascular drugs and therapy. - 1991. - Vol. 5, Suppl. 3. - P. 408. (1991)ext

Independent (non-Khavinson) studies

None catalogued. To date there are zero independent Western human trials of any Khavinson compound, in any year. Independent in-vitro data exists for Epitalon only (two 2025 studies). If a study belongs here, add it to non-khavinson-research.json and rebuild.

Reddit meta-scrape

No Reddit community discussion exists for this compound. This is honest reporting — the peptide has essentially zero anecdotal footprint in the biohacking community. Absence of anecdotes is not evidence of safety or efficacy, but it does mean there is no community-level signal to analyze.

Measurement protocol — concrete testable endpoints

Echo (ejection fraction), ECG, BNP, troponin, lipid panel.

All endpoints on one page: measurement-protocols.html · Evidence-tier legend: evidence-tiers.html