Subject of the first comprehensive independent Western functional screen (2026 mouse study) — returned essentially null results with positive controls behaving as expected.
Extract counterpart: None established — this compound exists only as a defined synthetic fragment.
Extract vs synthetic gap: the human outcome data (including the
266-patient mortality cohort) was collected on extracts; vendors sell synthetic fragments.
No head-to-head trial exists — evidence does not transfer between them.
Details →
Khavinson studies (7 matched, 2011–2021)
Keyword-filtered from the 472-publication database (khavinson.info). EXTRACT/SYNTHETIC
tags are title-text heuristics — verification is on the reader. Full tag legend:
evidence-tiers.html
[16] [Khavinson V., Linkova N., Kozhevnikova E., Trofimova S. EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer’s Disease. // Molecules. – 2021. – Vol. 26, Iss.1, 159. – 16 p.](https://khavinson.info/assets/files/skan/2021-khavinson_linkova_kozhevnikova.pdf) DOI: 10.3390/molecules26010159 (2021)untagDOI:10.3390/molecules26010159[PDF]
[49] Khavinson V., Linkova N., Kukanova E., Bolshakova A., Gainullina A., Tendler S., Morozova E., Tarnovskaya S., Vinski D., Bakulev V., Kasyanenko N. Neuroprotective Effect of EDR Peptide in Mouse Model of Huntington’s Disease. // Journal of Neurology and Neuroscience. – 2017. – Vol. 8, N 1:166. – P. 1-11. (2017)untag[PDF]
[91] Arutjunyan A., Kozina L., Stvolinskiy S., Bulygina Y., Mashkina A., Khavinson V. Pinealon prorects the rat offspring from prenatal hyperhomocysteinemia. // International Journal of Clinical Experimental Medicine. - 2012. - Vol. 5, N 2. - P. 179-185. (2012)untag[PDF]
[97] Khavinson V.Kh., Lin’kova N.S., Polyakova V.O., Kvetnoi I.M., Benberin V.V., D’yakonov M.M., Titkov Yu.S. Tetrapeptide H-Ala-Glu-Asp-Arg-OH Stimulates Expression of Cytoskeletal and Nuclear Matrix Proteins. // Bulletin of Experimental Biology and Medicine (Cell Technologies in Biology and Medicine). - 2012. - N 2, August. - P. 559-562. (n.d.)untag
[113] Khavinson V., Ribakova Y., Kulebiakin K., Vladychenskaya E., Kozina L., Arutjunyan A., Boldyrev A. Pinealon Increases Cell Viability by Suppression of Free Radical Levels and Activating Proliferative Processes. // Rejuvenation Research. - 2011. - Vol. 14, N 5. - P. 535-541. (2011)untag[PDF]
[10] Khavinson V., Linkova N., Kozhevnikova E., Kraskovskaya N., Ilina A. EDR peptide: perspectives of applying in neuroprotection. // International Symposium of Experts “Regenerative medicine and ageing”. – UAE, Dubai. – 01-02.02.2020. – Abstr. Book. – P. 25-26. (2020)syn[PDF]
[71] Arutyunian A., Bondarev A., Khavinson V., Kozina L. Excitotoxicity induced by homocysteine in neuronal and immune competent cells is prevented by synthetic peptide pinealon: mechanism of action and possible clinical application. // VII European Congress Healthy and Active Ageing for All Europeans - II. - Bologna, Italy. - Abstr.: Aging Clinical and Experimental Research. - 2011. - Vol. 23, Suppl. (n.d.)syn
Independent (non-Khavinson) studies
Pinealon (EDR) — 2026 independent Western mouse functional screen
independent
Result: Near-null. Safe but no significant geroprotective effect vs positive controls, only non-significant cognitive trend. Positive controls performed as expected.
Significance: First comprehensive functional screen of a Khavinson peptide by an independent Western lab. Returned essentially nothing.
Reddit meta-scrape
1 post mention (r/nkj7jq high-scoring guide on r/Nootropics) + independent mouse screen (2026).
Neutral / no-effect
Almost no Reddit discussion exists. The compound is barely known outside the Russian peptide community.
Negative reports
2026 independent Western mouse screen: near-null result. Safe but no significant geroprotective effect vs positive controls.
MEASURED vs VIBE: 0 measured, 0 subjective. No Reddit reports to analyze.
Common protocol: No established Reddit protocol consensus.
Key takeaway: Near-zero Reddit data. The only independent functional test (2026 mouse screen) returned near-null. This is the least-discussed and least-evidenced compound in the catalog.