The synthetic KE dipeptide bridge from thymus extract; some comparative studies suggest it reproduces part of the extract immunomodulatory effect — no equivalence trial.
Extract counterpart: Partial bridge to Thymalin: thymus extract contains the KE fragment among many other peptide species; the synthetic fragment may not reproduce full extract activity.
Extract vs synthetic gap: the human outcome data (including the
266-patient mortality cohort) was collected on extracts; vendors sell synthetic fragments.
No head-to-head trial exists — evidence does not transfer between them.
Details →
Khavinson studies (17 matched, 2000–2004)
Keyword-filtered from the 472-publication database (khavinson.info). EXTRACT/SYNTHETIC
tags are title-text heuristics — verification is on the reader. Full tag legend:
evidence-tiers.html
[89] [Sevostianova N.N., Linkova N.S., Polyakova V.O., Chervyakova N.A., Kostylev A.V., Durnova A.O., Kvetnoy I.M., Abdulragimov R.I., Khavinson V.Kh. Immunomodulating Effects of Vilon and Its Analogue in the Culture of Human and Animal Thymus Cells. // Bulletin of Experimental Biology and Medicine (Cell Technologies in Biology and Medicine)_. -_ 2013\. - Vol. 154. N 4. - P. 562-565.](https://khavinson (n.d.)untag[PDF]
[145] Lezhava T., Khavinson V., Monaselidze J., Jokhadze T., Dvalishvili N., Bablishvili N., Barbakadze S. Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people. // Biogerontology. - 2004. - N 5. - P. 73-79. (2004)ext[PDF]
[146] [Raikhlin N.T., Bukaeva I.A., Smirnova E.A., Yarilin A.A., Sharova N.I., Mitneva M.M., Khavinson V.Kh., Polyakova V.O., Trofimov A.V., Kvetnoi I.M. Expression of Argyrophilic Proteins in the Nucleolar Organizer Regions of Human Thymocytes and Thymic Epitheliocytes under Conditions of Coculturing with Vilon and Epithalon Peptides. // Bulletin of Experimental Biology and Medicine. - 2004. - Vol. 137 (n.d.)ext[PDF]
[160] Anisimov S.V., Bokheler K.R., Khavinson V.Kh., Anisimov V.N. Studies of the Effects of Vilon and Epithalon on Gene Expression in Mouse Heart using DNA-Microarray Technology. // Bulletin of Experimental Biology and Medicine. - 2002. - Vol. 133, N 3. - P. 293-299. (2002)ext[PDF]
[167] Khavinson V.Kh., Egorova V.V., Timofeeva N.M., Malinin V.V., Gordova L.A., Gromova L.V. Effect of Vilon and Epithalon on Glucose and Glycine Absorption in Various Regions of Small Intestine in Aged Rats. // Bulletin of Experimental Biology and Medicine. - 2002. - Vol. 133. N 5. - P. 494-496. (2002)untag
[176] Khavinson V.Kh., Timofeeva N.M., Malinin V.V., Gordova L.A., Nikitina A.A. Effect of Vilon and Epithalon on Activity of Enzymes in Epithelial and Subepithelial Layers in Small Intestine of Old Rats. // Bulletin of Experimental Biology and Medicine. - 2002. - Vol. 134, N 6. - P. 562-564. (2002)ext
[189] Khavinson V.Kh., Timofeeva N.M., Malinin V.V., Egorova V.V., Nikitina A.A. Effect of the Dipeptide Vilon on Activity of Digestive Enzyme in Rats of Various Ages. // Bulletin of Experimental Biology and Medicine. - 2001. - Vol. 131, N 6. - P. 583-585. (2001)untag
[191] Khavinson V.Kh., Yuzhakov V.V., Kvetnoi I.M., Malinin V.V., Popuchiev V.V., Fomina N.K. Immunohistochemical and Morphometric Analysis of Effects of Vilon and Epithalon on Functional Morphology of Radiosensitive Organs. // Bulletin of Experimental Biology and Medicine. - 2001. - Vol. 131, N 3. - P. 285-292. (2001)untag
[192] Pliss G.B., Mel’nikov A.S., Malinin V.V., Khavinson V.Kh. Inhibitory Effect of Peptide Vilon on the Development of Induced Rat Urinary Bladder Tumors in Rats. // Bulletin of Experimental Biology and Medicine. - 2001. - Vol. 131, N 6. - P. 558-560. (2001)syn
[195] Khavinson V.Kh., Anisimov V.N., Zavarzina N.Yu., Zabezhinskii M.A., Zimina O.A., Popovich I.G., Shtylik A.V., Malinin V.V., Morozov V.G. Effect of Vilon on Biological Age and Lifespan in Mice. // Bulletin of Experimental Biology and Medicine. - 2000. - Vol. 130, N 7. - P. 687-690. (2000)ext
[98] Ivanov S.D., Kondratyeva A.V., Kovanko E.G., Khavinson V.Kh. Influence of the «Neoselen» and Vilon preparations on consequences of radiation-mercury exposures with low doses. // VI European Congress of International Association of Gerontology and Geriatrics. - Saint Petersburg, Russia. - Abstr. book: Advances in gerontology. - 2007. - Vol. 20. - P. 38. (n.d.)both
[124] Oparina T.I., Mylnikov S.V., Prokopenko V.M., Arutjunyan A.V., Khavinson V.Kh. Protective effect of vilon on mitochondria in drosophila and rat. // International Ecologic Forum. - St.Petersburg, Russia. - Abstr.: Environment and human health. - 2003. - P. 531-533. (2003)syn
[125] Pshenkina N.N., Andreeva N.B., Veselova O.M., Murzina E.V., Khavinson V.Kh. The efficiency of the vilon at the experimental sublethal exposition to the sodium nitrite. // International Ecologic Forum. - St.Petersburg, Russia. - Abstr.: Environment and human health. - 2003. - P. 535-536. (2003)syn
[130] Anisimov S.V., Boheler K.R., Khavinson V.Kh., Anisimov V.N. Small peptides epitalon and vilon slow aging in CBA mice: microarray analysis of gene expression. // Meeting “Molecular genetics of aging”. - Cold Spring Harbor, New York. - Abstr. - 2002. - P. 14. (2002)syn
[132] Anisimov V.N., Khavinson V.Kh., Zavarzina N.Yu., Zabezhinski M.A., Popovich I.G., Anisimov S.V., Boheler K.R., Petrov N.N. Effect of Melatonin, Vilon and Epitalon on Life Span and Expression of 15,247 Genes in CBA Mice. // 1 st Conference on Functional Genomics of Ageing. - Seville, Spain. - Abstr. - 2002. - P68. (n.d.)syn
[157] Grigoriev E.I., Kotchnev I.N., Kudriavtseva T.A., Grigoriev A.E., Khavinson V.Kh. New peptide immunomodulators Vilon and Thymogen. Chemical and biophysical aspects of their action in the water medium. // 26 th European Peptide Symposium. - Montpellier, France. - Proc.: EDK. - 2001. - P. 475-476. (2001)syn
[171] Grigoriev E., Kotchnev I., Kudriavtseva T., Grigoriev A., Khavinson V. New peptide immunomodulators vilon and thymogen, chemical and biophysical aspects of their action in the water medium. // J. of Peptide Science. - 2000. - Vol. 6. Suppl. - P. 139. (2000)syn
Independent (non-Khavinson) studies
None catalogued. To date there are zero independent Western human trials of any Khavinson compound, in any year. Independent in-vitro data exists for Epitalon only (two 2025 studies). If a study belongs here, add it to non-khavinson-research.json and rebuild.
Reddit meta-scrape
0 dedicated posts in harvested corpus. Mentioned only in comparison guides.
Neutral / no-effect
No dedicated Reddit experience threads exist.
MEASURED vs VIBE: 0/0 — no user reports found.
Common protocol: Russian protocol: 100mcg/day SQ x 10 days, 3-6x/year.
Key takeaway: Essentially no Reddit community discussion exists. No user anecdotes to analyze.