Extract vs synthetic gap: the human outcome data (including the
266-patient mortality cohort) was collected on extracts; vendors sell synthetic fragments.
No head-to-head trial exists — evidence does not transfer between them.
Details →
Khavinson studies (9 matched, 2004–2019)
Keyword-filtered from the 472-publication database (khavinson.info). EXTRACT/SYNTHETIC
tags are title-text heuristics — verification is on the reader. Full tag legend:
evidence-tiers.html
[81] Khavinson V.Kh., Durnova A.O., Polyakova V.O., Tolibova G.H., Linkova N.S., Kvetnoy I.M., Kvetnaia T.V., Tarnovskaya S.I. Effects of Pancragen on the Differentiation of Pancreatic Cells During Their Ageing. // Bulletin of Experimental Biology and Medicine_. -_ 2013\. - Vol. 154. N 4 - P. 501-504. (2013)untag[PDF]
[84] Khavinson V.Kh., Sevostyanova N.N., Durnova A.O., Linkova N.S., Tarnovskaya S.I., Dudkov A.V., Kvetnaya T.V. Tetrapeptide Stimulates Functional Activity of Pancreatic Cells in Aging. // Advances in Gerontology. - 2013. - Vol. 3, N 3. - P. 220-224. (2013)untag[PDF]
[115] Korkushko O.V., Khavinson V.Kh., Shatilo V.B., Antonyk-Sheglova I.A., Bondarenko E.V. Prospects of Using Pancragen for Correction of Metabolic Disorders in Elderly People. // Bulletin of Experimental Biology and Medicine. - 2011. - Vol. 151, N 4. - P. 454-456. (2011)syn[PDF]
[127] Khavinson V.Kh., Gavrisheva N.A., Malinin V.V., Chefu S.G., Trofimov E.L. Effect of Pancragen on Blood Glucose Level, Capillary Permeability and Adhesion in Rats with Experimental Diabetes Mellitus. // Bulletin of Experimental Biology and Medicine. - 2007. - Vol. 144, N 4. - P. 559-562. (2007)syn
[134] Goncharova N.D., Vengerin A.A., Khavinson V.Kh., Lapin B.A. Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas. // Experimental Gerontology. - 2005. - Vol. 40. - P. 51-57. (2005)untag
[139] Goncharova N.D., Vengerin A.A., Khavinson V.Kh, Lapin B.A. Peptide Correction of Age-Related Hormonal Dysfunction of the Pancreas in Monkeys. // Bulletin of Experimental Biology and Medicine. - 2004. - Vol. 138, N 7. - P. 80-83. (2004)untag[PDF]
[20] [Shatilo V., Korkushko O., Khavinson V. Effecacy of Pancragen Tetrapeptide Thearpy in Senior Patients with Diabetes Mellitus Type II. // International Association of Gerontology and Geriatrics European Region. Congress 2019. – Sweden, Gothenburg. – 23-25.05.2019. – Official IAGG-ER 2019 website. – 1 p.](https://khavinson.info/assets/files/skan/efficacy-of-pancragen-tetrapeptide-thearpy-in-senior-p (2019)syn[PDF]
[43] Khavinson V., Tarnovskaya S, Linkova N. Peptide Regulates Cell Proliferation, Differentiation and Apoptosis in the Pancreas During Ageing. // The International Association of Gerontology and Geriatrics European Region 8-th Congress. Dublin 2015. – Irish, Dublin. – 2015. – Irish Ageing Studies Review: Abstr. – Vol. 6, Iss. 1. – P. 194-195. (2015)untag
[50] Khavinson V.Kh., Tarnovskaya S.I., Linkova N.S. Peptide KEDW regulates B-cell differentiation during ageing of pancreatic cells. // 9th European Congress of Biogerontology. – Seville, Spain. – 2014. – Abstr. Book. – P. 93. (2014)untag
Independent (non-Khavinson) studies
None catalogued. To date there are zero independent Western human trials of any Khavinson compound, in any year. Independent in-vitro data exists for Epitalon only (two 2025 studies). If a study belongs here, add it to non-khavinson-research.json and rebuild.
Reddit meta-scrape
No Reddit community discussion exists for this compound. This is honest reporting — the peptide has essentially zero anecdotal footprint in the biohacking community. Absence of anecdotes is not evidence of safety or efficacy, but it does mean there is no community-level signal to analyze.