Endothelium-targeted tripeptide; note the same KED sequence is marketed under different organ claims (Livagen = liver, Vesugen = vessels) — a red flag for tissue specificity.
Extract counterpart: None established — this compound exists only as a defined synthetic fragment.
Extract vs synthetic gap: the human outcome data (including the
266-patient mortality cohort) was collected on extracts; vendors sell synthetic fragments.
No head-to-head trial exists — evidence does not transfer between them.
Details →
Khavinson studies (4 matched, 2015–2020)
Keyword-filtered from the 472-publication database (khavinson.info). EXTRACT/SYNTHETIC
tags are title-text heuristics — verification is on the reader. Full tag legend:
evidence-tiers.html
[63] Khavinson V.Kh., Tarnovskaya S.I., Linkova N.S., Gutop E.O., Elashkina E.V. Epigenetic Aspects of Peptidergic Regulation of Vascular Endothelial Cell Proliferation in Aging. // Advances in Gerontology. – 2015. – Vol. 5, No 4. – P. 219-224. (2015)untag[PDF]
[1] Ilina A., Kraskovskaya N., Linkova N., Khavinson V. KED peptide prevents synaptic contacts elimination of hippocampus neurons in an in vivo Alzheimer’s disease models. // Hybrid conference “Systems biology and systems physiology: regulation of biological networks”. – Estonia, Tallinn. – 25-27.08.2021. – Abstr. – P. 23-24. (n.d.)syn[PDF]
[3] [Khavinson V., Linkova N., Ashapkin V., Shilovsky G., Vanuyshin B. KE and KED peptides regulate PARP and SIRT gene expression during replicative and stationary human mesenchymal stem cells aging. // Hybrid conference “Systems biology and systems physiology: regulation of biological networks”. – Estonia, Tallinn. – 25-27.08.2021. – Abstr. – P. 8.](https://khavinson.info/assets/files/pdf/ottisk-tez- (n.d.)syn[PDF]
[6] [Caputi S., Sinjari B., Diomede F., Trubiani O., Mironova E., Khavinson V. The effect of KED tripeptide on neuronal differentiation of human gingival mesenchymal stem cells. // International Symposium of Experts “Regenerative medicine and ageing”. – UAE, Dubai. – 01-02.02.2020. – Abstr. Book. – P. 11.](https://khavinson.info/assets/files/skan/the-effect-of-ked-tripeptide-on-neuronal-differentiatio (2020)syn[PDF]
Independent (non-Khavinson) studies
None catalogued. To date there are zero independent Western human trials of any Khavinson compound, in any year. Independent in-vitro data exists for Epitalon only (two 2025 studies). If a study belongs here, add it to non-khavinson-research.json and rebuild.
Reddit meta-scrape
No Reddit community discussion exists for this compound. This is honest reporting — the peptide has essentially zero anecdotal footprint in the biohacking community. Absence of anecdotes is not evidence of safety or efficacy, but it does mean there is no community-level signal to analyze.